Iron Homeostasis Dysregulation, Oro-Gastrointestinal Microbial Inflammatory Factors, and Alzheimer’s Disease: A Narrative Review

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Iron Homeostasis Dysregulation, Oro-Gastrointestinal Microbial Inflammatory Factors, and Alzheimer’s Disease: A Narrative Review

Alzheimer's disease (AD) is a common form of dementia and a neurodegenerative disorder that affects the nervous system and patients’ cognitive abilities. Current evidence implies that iron dysregulation and bacterial inflammatory factors may be associated with the oral and gut microbiome as critical factors in developing AD. Iron homeostasis disruption may lead to excessive iron accumulation within the cell, forming aggressive reactive oxygen sp…