Investigation of Integrase Inhibitor Resistance Mutations in gp41 in Clinical Samples - Science in Vancouver

Investigation of Integrase Inhibitor Resistance Mutations in gp41 in Clinical Samples - Science in Vancouver

Mutations conferring resistance to HIV Integrase Strand Transfer Inhibitors (INSTI) can occur outside integrase, including in env gp41, in vitro, but it remains unclear whether these arise under INSTI selection in vivo. Using a large database of clinically-derived HIV sequences linked to antiretroviral treatment histories, we sought to identify mutations in gp41 associated with INSTI exposure by comparing integrase and gp41 amino acid frequencie…