Deep generative design of RNA aptamers using structural predictions

Deep generative design of RNA aptamers using structural predictions

RNAs represent a class of programmable biomolecules capable of performing diverse biological functions. Recent studies have developed accurate RNA three-dimensional structure prediction methods, which may enable new RNAs to be designed in a structure-guided manner. Here, we develop a structure-to-sequence deep learning platform for the de novo generative design of RNA aptamers. We show that our approach can design RNA aptamers that are predicted…

Novel biosensor illuminates plant RNA in real time

Scientists at Oak Ridge National Laboratory have developed a first-ever method of detecting ribonucleic acid, or RNA, inside plant cells using a technique that results in a visible fluorescent signal. The technology can help researchers detect and track changes in RNA and gene expression in real time, providing a powerful tool for the development of hardier bioenergy and food crops and for detection of unwanted plant modifications, pathogens and

Two professors are conducting pioneering and innovative research in this field, whose potential therapeutic benefits are extremely promising. The RNA branch of biotechnology continues to reveal its secrets. Pictured: Angela Pearson, professor at INRS. The functions of RNA (ribonucleic acid) and its associated therapeutic mechanisms have been of interest to scientists for many years. Among the general public, its curative potential has become wid…