Immature NK cells in donor cord blood can undermine CAR NK cell therapy activity

Immature NK cells in donor cord blood can undermine CAR NK cell therapy activity

The composition of donor cord blood may play a critical role in the success of chimeric antigen receptor (CAR) natural killer (NK) cell therapies.

Donor Cord Blood Composition May Influence CAR NK Cell Therapy Outcomes

The composition of donor cord blood may play a critical role in the success of chimeric antigen receptor (CAR) natural killer (NK) cell therapies. A small population of immature NK cells present in donor cord blood can undermine the activity of CAR NK cell therapy by redirecting potent immune cells away from tumors and causing them to attack one another, according to researchers from The University of Texas MD Anderson Cancer Center.