IBS Linked to Elevated Triglyceride Levels in Large-Scale GWAS

Genetic research reveals surprising metabolic pathway for irritable bowel syndrome

Irritable bowel syndrome (IBS) is a common condition that affects more than 10% of the general population, causing recurrent abdominal pain, bloating, constipation and diarrhea.

IBS Linked to Elevated Triglyceride Levels in Large-Scale GWAS

A genome-wide association study (GWAS) among almost 2.8 million individuals has revealed a causal link between irritable bowel syndrome (IBS) and elevated triglyceride levels. IBS affects between 5% and 15% of the general population, is more common in women, and considerably reduces quality of life. It is known as a disorder of gut–brain interaction, but understanding of underlying disease mechanisms is limited, which has hindered the developmen…

Genetic study links IBS to lipid metabolism and triglyceride regulation

Irritable bowel syndrome (IBS) is a common condition that affects more than 10% of the general population, causing recurrent abdominal pain, bloating, constipation and diarrhea. IBS is considered a disorder of gut-brain interaction, and previous research, including genetic research, has established links to nerve signaling, the nervous system and other conditions including anxiety and mood disorders. The exact biological mechanisms, however, hav…