The mosquito-borne Zika virus is known for causing microcephaly, a birth defect in which abnormal brain development results in a smaller-than-expected head.

News Medical

United States

Study reveals how Zika virus hijacks host protein for reproduction

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Ian Birkby

The mosquito-borne Zika virus is known for causing microcephaly, a birth defect in which abnormal brain development results in a smaller-than-expected head. A new study shows that the Zika virus hijacks a host protein called ANKLE2, which happens to be important for brain development, to assist its own reproduction. Because Zika, unlike most related viruses, can cross the placenta, this can have disastrous consequences in pregnancy.

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Science Daily

Daniel Hogan

Wrong place, wrong time: Why Zika virus hijacks a protein needed for brain growth

Zika virus, infamous for causing microcephaly, manipulates a host protein called ANKLE2 to assist its replication, which also affects brain development. This process differs from other mosquito-borne viruses like dengue and yellow fever, as Zika uniquely crosses the placental barrier to harm fetuses. Zika Virus and Microcephaly: A Dangerous Connection The mosquito-borne Zika virus is [...]

Sci Tech Daily

How Zika Virus Turns Brain Proteins Into Hidden Weapons

A study conducted by the University of California and published in the journal mBio indicates that the Zika virus hijacks a human protein called ANKLE2, of paramount importance for brain development, for its own benefit. For this reason, in cases of infection in pregnant women, as Zika is able to cross the placenta, it ends up causing cases of microcephaly, a condition in which the baby's brain forms smaller than expected. “It's a situation wher…

Estudo conduzido pela Universidade da Califórnia e publicado no periódico mBio indica que o vírus Zika sequestra uma proteína humana chamada ANKLE2, de suma importância para o desenvolvimento cerebral, para seu próprio benefício. Por esse motivo, em casos de infecção em gestantes, como o Zika é capaz de atravessar a placenta, ele acaba por provocar casos de microcefalia, condição em que o cérebro do bebê se forma de um tamanho menor que o espera…

Zika: sequestro de gene após infecção causa microcefalia, diz estudo

Quadra

State of São Paulo

Brazil

Zika: gene sequestration after infection causes microcephaly, says study

Zika virus (ZIKV) is a mosquito-borne orthoflavivirus that can cause birth defects, including microcephaly, a condition in which head and brain size are significantly reduced at birth. The collective results of the newly reported study involving work in human cell lines, fruit flies, and mosquito cells, have shown how Zika virus hijacks a host protein called ANKLE2, which is important for brain development, to assist its own replication. The new…

Study reveals how Zika virus hijacks host protein for reproduction

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