How the developing human brain takes instructions: Two studies reveal what guides its most important stem cells
Researchers found human cortical stem cells are steered by metabolism and direct thalamic contact, two signals that shape which neurons the cortex produces.
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5 Articles
Scientists reveal the hidden instructions that build the human brain
UCLA researchers have discovered two powerful influences that help guide how the human brain forms before birth. Radial glia, stem cells responsible for producing much of the cerebral cortex, change their behavior depending on how they process glucose and on physical contact with signals arriving from the thalamus. Those signals can alter which types of neurons are produced, including upper-layer neurons that are especially prominent in humans.
Two recent studies have revealed cellular mechanisms that play an important role in guiding the development of the human brain before birth, showing that stem cells responsible for forming a large part of the cerebral cortex respond to factors associated with the process of food acting and signals coming from other areas of the developing brain.
How the developing human brain takes instructions: Two studies reveal what guides its most important stem cells
As the human brain takes shape before birth, a remarkable type of stem cell helps give it many of the features that make it distinctly human. These cells, called radial glia, make billions of decisions that determine which kinds of brain cells are created, when they appear and how the cortex—the seat of thought, memory and language—takes form.
How the Developing Human Brain Takes Instructions: Two UCLA Studies Reveal What Guides Its Most Important Stem Cells
In two new studies, UCLA researchers used lab-grown brain organoids, donated human tissue and fused "assembloids" to investigate how radial glia — the stem cells that build the human cerebral cortex — decide which types of brain cells to make.
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