Study Uncovers How the Brain's 'Memory Replay' Process Is Impaired in Alzheimer's Disease

Study uncovers how the brain's 'memory replay' process is impaired in Alzheimer's disease

Memory dysfunction in Alzheimer's disease may be linked to impairment in how the brain replays our recent experiences while we are resting, according to a new study in mice by University College London (UCL) scientists.

Scientists Found a Hidden Brain Failure Behind Alzheimer’s Memory Loss

A new study in mice suggests that memory problems in Alzheimer’s disease may stem from a breakdown in how the brain replays recent experiences during periods of rest. The research was carried out by scientists at University College London (UCL) and focuses on a brain process believed to be essential for forming and maintaining memories. [...]

How the brain's 'memory replay' goes wrong in Alzheimer's disease

Memory dysfunction in Alzheimer's disease may be linked to impairment in how the brain replays our recent experiences while we are resting, according to a new study in mice by University College London (UCL) scientists. The researchers say their findings could help scientists develop drug treatments targeting this impaired brain function, or help design new tests for early diagnosis. The work is published in Current Biology.

Hippocampal Replay Persists but Loses Structure in Alzheimer’s Model

Place cells—the hippocampal neurons discovered by Nobel laureate John O’Keefe, PhD—normally fire in crisp, rapid sequences that replay our recent experiences during rest, helping memories take hold. But in Alzheimer’s disease, that internal rehearsal appears to become undone. In a new study from University College London (UCL), researchers report that hippocampal replay still occurs in an Alzheimer’s mouse model, yet the sequences lose their str…

How the brain’s ’memory replay’ goes wrong in Alzheimer’s disease

29.01.2026 - Memory dysfunction in Alzheimer's disease may be linked to impairment in how the brain replays our recent experiences while we are resting, according to a new study in mice by UCL scientists.