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How Somatic Mutations and Genome Mosaicism Shape Aging and Disease
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How Somatic Mutations and Genome Mosaicism Shape Aging and Disease
Aging may leave a genetic record in nearly every tissue of the human body, written not in the DNA inherited at conception but in mutations acquired during life. A review by E. Pan, A. Maslov and J. Vijg, published in Experimental & Molecular Medicine, examines how these somatic mutations generate genome mosaicism and influence aging, cancer and other diseases. The central message is both unsettling and scientifically powerful: the body is not ge…
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