How One Controversial Study Shaped 20 Years of Menopause Care
UNITED STATES, JUL 21 – The FDA panel revisits the 2002 Women’s Health Initiative findings amid calls to update hormone therapy guidance after evidence showed breast cancer risk was small and often misreported.
- That day, the NIH stopped the estrogen-plus-progestin arm of the WHI trial, citing increased blood clots, stroke, heart disease, and breast cancer in women, without attribution.
- The long-term Women’s Health Initiative trial commenced in 1991 as a $625 million, nine-year study evaluating conjugated equine estrogen plus progestin and conjugated equine estrogen alone regimens.
- After the WHI findings, up to 91,000 women died prematurely from conditions HRT might have prevented, study published in 2013, highlighting the impact on mortality.
- Amid growing research momentum, the FDA convened an expert panel and experts urged removal of the black box warning on vaginal estrogen, supporting policy updates.
- Amid growing advocacy, experts now argue that recent data shows benefits of HRT outweigh risks for most women, prompting a shift in menopause care.
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17 Articles
'Cougar Puberty’ Is the Internet’s Cool New Name for a Dreaded Phase of Life
There’s a new term making the rounds on TikTok (oh, good), and it’s doing what only TikTok can do: slapping a sexy-sounding label on a brutally unsexy life phase. Perimenopause, the stretch of years before menopause officially kicks in, is now being called “cougar puberty.” And depending on who you ask, it either sounds empowering or downright absurd. “You know what the cool kids are calling it now?” creator @radiant.rewind said in a viral video…
New studies suggest that symptoms of menopause may be indicative of a person's future health.


People's Pharmacy: Estrogen did not raise breast cancer risk
Q. People worry about the problems of hormone replacement therapy. I know one case doesn’t prove anything, but I took Premarin for 26 years with no negative effects.
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How one controversial study shaped 20 years of menopause care | News Channel 3-12
Hone Health How one controversial study shaped 20 years of menopause care By now, many women navigating perimenopause or menopause know the headline: In 2002, a study linked hormone replacement therapy (HRT) to an increased risk of breast cancer. Overnight, women abandoned treatment. Doctors stopped prescribing it. Years later, we learned the data had been misinterpreted, but the damage was already done. The study—one arm of the Women’s Health I…
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