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How Mycobacterium tuberculosis safeguards itself from foreign DNA

IISc team identified Lsr2 protein’s mechanism to silence AT-rich foreign DNA in tuberculosis bacteria, potentially aiding drug development to stop infection.

Summary by Phys.org
Researchers at the Indian Institute of Science (IISc), with collaborators from the Institute of Mathematical Sciences (IMSc), have discovered how a key protein in the tuberculosis bacterium helps protect it from the influence of foreign DNA inserted into its genome. Understanding how this protein—called Lsr2—functions could help develop drugs that target it, thereby aiding in the fight against TB.

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The Hindu broke the news in India on Friday, January 9, 2026.
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