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High meat consumption may protect against cognitive decline in people with a specific Alzheimer’s gene
Swedish study of 2,100+ adults found APOE4 carriers consuming about 870g unprocessed meat weekly had 55% lower dementia risk and slower cognitive decline over 15 years.
- Researchers at the Karolinska Institutet in Sweden found that higher consumption of unprocessed meat may protect against cognitive decline in seniors carrying specific high-risk APOE gene variants, based on a study of over 2,100 adults followed for 15 years.
- Because the APOE4 variant is the oldest form of the gene, arising when ancestors consumed animal-based diets, scientists hypothesize that carriers may metabolically benefit from such intake today.
- The population-based cohort study followed 2,157 older adults for 15 years, with all participants dementia-free at baseline; the highest meat intake group consumed a median of 870 grams per week.
- While unprocessed meat showed protective effects for APOE4 carriers, lead investigator Jakob Norgren noted that processed meat was linked to higher dementia risk across all genetic backgrounds regardless of genotype.
- Clinical trials are now needed to develop personalized nutrition plans, as Norgren emphasized the current observational study cannot prove causation; intervention research could eventually tailor dietary recommendations to individual APOE genotypes.
8 Articles
8 Articles
High meat consumption may protect against cognitive decline in people with a specific Alzheimer's gene
Older adults carrying a specific genetic variation linked to Alzheimer’s disease might actually protect their brain health by eating a diet high in meat. A recent study published in JAMA Network Open suggests that personalized dietary recommendations based on genetics could help prevent cognitive decline in a large portion of the global population. Every person carries a gene called APOE, which provides instructions for making a protein that hel…
Seniors Who Eat More Meat Are Less Likely to Develop Dementia Study Find
Researchers in Sweden recently found that seniors were able to offset a genetic risk for Alzheimer’s disease by consuming more meat. The study authors say that their findings suggest that conventional dietary advice may be unfavorable to a subgroup of the population who carry the APOE gene. Now infamous, APOE is a gene that confers […] The post Seniors Who Eat More Meat Are Less Likely to Develop Dementia Study Find appeared first on Good News N…
Higher meat intake may slow cognitive decline in older adults with APOE ε4
In older Swedish adults, higher meat intake was associated with slower cognitive decline and lower dementia risk among people carrying APOE ε3/ε4 or ε4/ε4, but not among other genotype groups. A higher processed-to-total meat ratio was linked to worse dementia outcomes, while unprocessed red meat and poultry showed no substantial difference.
Meat Consumption and Cognitive Health by APOE Genotype
In this study, higher meat consumption was associated with better cognitive trajectories and lower dementia risk among individuals with APOE34/44 genotypes. The expected cognitive disadvantage among individuals with APOE34/44 genotypes was not observed at high meat consumption, suggesting clinical a …
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