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Shingles Vaccine Might Protect Against Heart Attack, Stroke

Global study shows herpes zoster vaccination is linked to an 18% lower risk of heart attack and stroke, suggesting cardiovascular benefits beyond infection prevention.

  • A global analysis reported the first global systematic literature review finding the herpes zoster vaccine could lower heart attack and stroke risk by nearly 20%, presented at the European Society of Cardiology Congress in Madrid.
  • Because shingles can inflame blood vessels, researchers note varicella-zoster virus invades vessels causing inflammation, and a previous large study published in the European Heart Journal earlier this year found vaccinated people had a 23 per cent lower cardiovascular risk.
  • Combined data from trials and observational studies revealed an 18 per cent lower cardiovascular risk in adults aged 18 and above, a 16 per cent reduction in adults aged 50 and older, and a 21 per cent lower risk with Shingrix.
  • The NHS announced 300,000 more people will become eligible for the shingles vaccine from 1 September, while study authors called for additional research and peer review to confirm findings.
  • Given the observational nature of most data, researchers say almost all evidence came from observational studies prone to bias and cannot prove causality, though confirmation could broaden cardiovascular disease prevention strategies despite unclear VZV vascular effects.
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Shingles Vaccine Might Protect Against Heart Attack, Stroke

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University of Minnesota Twin Cities… broke the news in on Thursday, August 28, 2025.
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