HBsAg Vaccine Harnesses T Cells to Eradicate Tumors

HBsAg-Tagged Tumor Vaccine System Eliminates Solid Tumours through Virus-Specific Memory T Cells

Researchers developed a hepatitis B surface antigen (HBsAg)-tagged tumour vaccine system (H-TVAC). H-TVAC leverages HBsAg-specific memory T cells from a HBsAg mRNA vaccine to target and lyse HBsAg-tagged tumour cells using the vaccinia virus. [Nature Biomedical Engineering] Abstract

HBsAg Vaccine Harnesses T Cells to Eradicate Tumors

In the persistent battle against cancer, innovative methods for generating effective immunotherapeutic strategies remain a central focus of medical research. One of the most significant hurdles that researchers face is the identification of immunogenic antigens that are present uniformly across heterogeneous solid tumors. Unlike microbes, which have well-defined antigens capable of stimulating robust immune responses, […]