Bioengineered Platform Uses Bacteria to Sneak Viruses Into Tumors

Acting as a Trojan Horse, Viruses Can Use Bacteria to Kill Tumors From the Inside

Engineered viruses using bacteria as a Trojan horse could be the next big thing in cancer treatment.

Bioengineered platform uses bacteria to sneak viruses into tumors

Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team. In a study published in Nature Biomedical Engineering, the Synthetic Biological Systems Lab shows how their system hides a virus inside a tumor-seeking bacterium, smuggles it past the immune system, and unleashes it inside cancerous tumors.

Bacteria and Viruses Join Forces in New Cancer-Killing Therapy

Researchers have developed CAPPSID, a novel cancer therapy that teams bacteria and viruses to infiltrate and destroy tumors. The system hides an oncolytic virus inside Salmonella typhimurium, which naturally migrates into tumors, shielding the virus from immune detection.

Using bacteria to sneak viruses into tumors - Scientific Inquirer

Researchers at Columbia Engineering have built a cancer therapy that makes bacteria and viruses work as a team. In a study published today in Nature Biomedical Engineering, the Synthetic Biological Systems Lab shows how their system hides a virus inside a tumor-seeking bacterium, smuggles it past the immune system, and unleashes it inside cancerous tumors.  The new platform combines the bacteria’s tendency to find and attack tumors with the viru…

Harnessing Bacteria to Deliver Viruses Directly into Tumors

Researchers at Columbia Engineering have pioneered a groundbreaking cancer therapy that harnesses the synergistic power of bacteria and viruses working in concert. This innovative approach, detailed in a recent publication in Nature Biomedical Engineering, introduces a novel delivery system wherein a tumor-targeting bacterium conceals a therapeutic virus, effectively bypassing the immune system and unleashing a potent oncolytic assault directly …