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Gut microbiome changes may signal Parkinson's disease risk
The gut microbial pattern identified in 271 Parkinson’s patients and 43 high-risk carriers may help flag disease years before symptoms, researchers said.
- University College London researchers identified a distinct gut "microbial signature" that serves as a "warning signal" for Parkinson's disease years before motor symptoms appear.
- The study analyzed data from 271 Parkinson's patients, 43 GBA1 variant carriers with no symptoms, and 150 healthy controls, revealing an "intermediate" microbiome profile in at-risk individuals.
- Researchers corroborated findings across cohorts in Korea, Turkey, and London, totaling 638 Parkinson's patients and 319 healthy controls, proving the microbial signature's consistency across cultures.
- Co-Lead author Professor Stanislav Dusko Ehrlich said gut analysis could enable doctors to "identify individuals who are at risk," allowing early dietary interventions to reduce Parkinson's risk.
- While promising, the microbiome is "one piece of a complex puzzle" involving genetics and environment; trials are testing whether targeting these pathways can slow Parkinson's progression.
12 Articles
12 Articles
University College London study reveals that intestinal microbiome analysis can identify Parkinson, years before the first symptoms. 638 people from different countries were examined.
A team of scientists has found that approximately 25% of the microbiome already has alterations in people at risk and that it could use to identify individuals who are at an early stage and will progress towards Parkinson’s disease.
Gut microbiome changes may signal Parkinson's disease risk
Analysis of microbes in the gut can reveal whether a person faces an elevated risk of Parkinson's disease, before they have developed any symptoms, suggests a new study led by University College London (UCL) researchers. The scientists found that people with Parkinson's disease have a distinctive makeup of gut microbes, as do healthy individuals who are genetically at risk of Parkinson's disease, they report in the new Nature Medicine study.
One study identified specific changes in the intestinal microbiota of hundreds of patients or people at risk, allowing to imagine screening tests and targeted accompaniment.
The discovery of a set of Parkinson-specific markers in the intestinal microbiota opens the way for testing to identify people at risk of developing the disease.
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