Glucosamine supplements may speed memory loss from Alzheimer’s, new research shows
Researchers found glucosamine use was linked to a 25% higher risk of dementia progression and a 25% increase in mortality among Alzheimer’s patients.
- Researchers reported in Nature Metabolism on Tuesday that a retrospective study of 65,000 patients found glucosamine use correlates with a 25% higher risk of progression from mild cognitive impairment to Alzheimer's disease.
- University of Florida neuroscientists discovered the Alzheimer's brain adds excessive sugar structures to proteins through N-glycosylation; glucosamine crosses the blood-brain barrier and fuels this overactive system.
- In genetically modified mice, the supplement significantly increased sugar attachment to proteins, causing deficits in 'social memory,' noted senior author Ramon Sun, Ph.D., of the University of Florida McKnight Brain Institute.
- Matt Gentry, Ph.D., chair of the University of Florida Department of Biochemistry and Molecular Biology, called the findings 'very provocative' but noted the study shows association rather than causation.
- With more than 40 million Americans using the supplement annually, researchers hope these results will prompt investigation into metabolic dysfunction as a targetable pathway for combating Alzheimer's disease.
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Popular over-the-counter supplement linked to faster Alzheimer’s decline, study sugge
Researchers found glucosamine use was linked to a 25% higher risk of progression from mild cognitive impairment to dementia and a 25% higher mortality risk among dementia patients, but experts stress the findings do not prove cause and effect
A new US study provides troubling evidence of a link between a joint pain drug and Alzheimer's disease.
A popular dietary supplement, glucosamine, may be linked to faster progression of Alzheimer's disease, according to new research.
Widely used glucosamine may speed dementia progression and raise death risk, study warns
For older adults, an over-the-counter remedy commonly taken for joint pain may come with a lesser-known concern. A study has linked the common supplement glucosamine, which is often used to treat arthritis, to faster decline in people with mild cognitive impairment, dementia, and Alzheimer's. University of Florida researchers reported that glucosamine users had 25% higher odds of progressing from mild cognitive impairment into dementia. In patie…
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