GLP-1s in Neurodegenerative Disease: Hope or Halt?

Postsynaptic M4 Signaling Mirrors Dopamine Loss Patterns

In the relentless quest to unravel the complexities of Parkinson’s disease, a groundbreaking new study sheds unprecedented light on the molecular adaptations occurring within the brain’s circuitry as the disease progresses. Researchers Nielsen and Ford have meticulously charted the intricate changes in muscarinic M4-receptor signaling along the direct pathway neurons of the basal ganglia, revealing how these postsynaptic adaptations closely shad…

GLP-1s in Neurodegenerative Disease: Hope or Halt?

Neurologists Indu Subramanian and Lorraine Kalia discuss the data on GLP-1 receptor agonists in neurodegenerative diseases and the recent study on exenatide in Parkinson’s disease.