Glioblastoma-Instructed Astrocytes Suppress Tumor-Specific T Cell Immunity

Targeting Astrocytes Could Boost Glioblastoma Treatment

Researchers at Harvard Medical School, in collaboration with the University of Freiburg in Germany and McGill University in Canada, have identified a new therapeutic target for glioblastoma, the deadliest form of brain cancer. In a study published in Nature, the team found a subtype of astrocyte cells that suppresses immune activity against glioblastoma and showed that inactivating these astrocytes can enhance tumor immunity and extend survival …

Glioblastoma-Instructed Astrocytes Suppress Tumor-Specific T Cell Immunity

The authors used single-cell and bulk RNA sequencing of clinical glioblastoma samples and samples from preclinical models, multiplexed immunofluorescence, in vivo CRISPR-based cell-specific genetic perturbations and in vitro mouse and human experimental systems to study the role of astrocytes in the immune response to glioblastoma. [Nature] Abstract