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Gilead Boosts Immunology Pipeline with over $2 Billion Buyout of Ouro Medicines

Gilead to pay $1.675 billion upfront plus $500 million in milestones for OM336, a BCMA-targeted T cell engager advancing autoimmune disease treatment.

  • On Monday, Gilead Sciences announced a definitive agreement to acquire Ouro Medicines for $1.675 billion in upfront cash, plus up to $500 million in milestone payments, to expand its inflammation pipeline.
  • Gilead is diversifying beyond its core HIV and oncology franchises to target immunology and build broader growth. The acquisition secures Ouro's clinical-stage BCMAxCD3 bispecific T-cell engager, gamgertamig , for treating severe autoimmune diseases.
  • Belgian partner Galapagos may lead gamgertamig development while absorbing Ouro's operating assets under advanced discussions. Keymed Biosciences, which licensed the program to Ouro, expects a total potential payout of about $320 million from the acquisition.
  • OM336 is currently in Phase 1/2 studies for autoimmune indications including AIHA and ITP. The treatment received Fast Track and Orphan Drug Designation from the FDA, accelerating its regulatory pathway.
  • This marks Gilead's second major M&A in a month, following the $7.8 billion takeover of Arcellx. Chief Medical Officer Dietmar Berger said the framework "complements our expanding inflammation pipeline" and reflects investment in innovative science.
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Gilead’s expectation is to strengthen its drug portfolio for autoimmune diseases

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Reuters broke the news in United Kingdom on Monday, March 23, 2026.
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