Genetically Modified Hookworms Could Make Therapeutics in a Host
4 Articles
4 Articles
Genetically modified worms can be used against various diseases.
Researchers have genetically modified a parasitic worm to produce antibodies directly in the body of its host. Tested on hamsters, this concept opens a radically new way to administer treatments against poisons, diabetes or inflammatory diseases — using a parasite that has been infecting humanity for millions [...]
Scientists have for the first time genetically modified parasitic worms so that they produce and deliver drugs directly within their host bodies.
Genetically modified hookworms could make therapeutics in a host
Researchers at Washington University have genetically engineered hookworms to produce and secrete a human antibody, creating a “living pharmaceutical biofactory,” according to the study published in Nature Communications. To survive within the human gut, hookworms secrete over 800 molecules to modulate inflammation and maintain homeostasis. “We thought: what if we make it secrete one more… The post Genetically modified hookworms could produce …
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