Genetic Study Reveals How DNA Repeats Expand with Age

Genetic study reveals how DNA repeats expand with age

An analysis of genetic data from over 900,000 people shows that certain stretches of DNA, made up of short sequences repeated over and over, become longer and more unstable as we age.

Scientists Just Found a New Genetic “Glitch” Linked to Severe Health Problems

Scientists discovered that aging DNA repeats expand at wildly different speeds—and in some people, the consequences can be devastating. A sweeping genetic study drawing on data from more than 900,000 people reveals that some parts of human DNA become increasingly unstable over time. These regions consist of very short genetic sequences that repeat again and [...]

Insights into DNA repeat expansions among 900,000 biobank participants

Expansions and contractions of tandem DNA repeats generate genetic variation in human populations and in human tissues. Some expanded repeats cause inherited disorders and some are also somatically unstable1,2. Here we analysed DNA sequencing data from over 900,000 participants in the UK Biobank and the All of Us Research Program using computational approaches to recognize, measure and learn from DNA-repeat instability. Repeats at different loci…

Expanded DNA Repeats Offer Blood-Based Indicator for Genetic Disease Treatments

While lifestyle modifications may go some way to delay the signs of aging, research from two transatlantic biobanks has revealed the importance of genes in determining the rate at which DNA mutates as we grow older. The Nature study revealed dozens of genes that regulate the expansion of DNA repeats—in which short genetic sequences become longer and more unstable with age. It showed these expanded DNA repeats are present in most people’s genomes…

Genetic Study Finds Tandem DNA Repeats Lengthen With Age and Link to Kidney and Liver Diseases

A recent analysis of genetic data from more than 900,00 […] The post Genetic Study Finds Tandem DNA Repeats Lengthen With Age and Link to Kidney and Liver Diseases first appeared on GeneOnline News. The post Genetic Study Finds Tandem DNA Repeats Lengthen With Age and Link to Kidney and Liver Diseases appeared first on GeneOnline News.