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Deafness Reversed: Single Injection Brings Hearing Back Within Weeks

CHINA, JUL 3 – A single synthetic virus injection restored hearing in all 10 patients aged 1 to 24 with OTOF gene mutations, with improvements seen within one month, study shows.

  • On July 3, 2025, researchers at Karolinska Institutet reported a gene therapy restoring hearing in ten patients across five hospitals in China.
  • This therapy targets OTOF gene mutations causing congenital deafness by delivering a healthy gene via a harmless virus in a single injection.
  • Participants aged one to 24 showed rapid hearing gains, with younger children, especially ages five to eight, demonstrating the greatest improvement.
  • Hearing improved significantly, with average perceptible sound reducing from 106 decibels to 52, and no serious side effects observed during a year-long follow-up.
  • Researchers, including Dr. Duan, view this as a major step toward treating various genetic deafness types and are expanding work to other genes like GJB2 and TMC1.
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The Medical Republic broke the news in on Thursday, July 3, 2025.
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