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Groundbreaking Therapy Restores Deaf’s Hearing
- Published in Nature Medicine, Karolinska Institute and Chinese hospitals report that AAV-OTOF gene therapy improved hearing in all 10 patients aged 1.5 to 23.9 years.
- Deafness from OTOF gene mutations impairs sound transmission despite healthy inner ear structures, making gene therapy a promising treatment approach.
- Objective tests show a 62% average hearing gain and no serious adverse reactions over 6–12 months, confirming safety and effectiveness.
- Most patients regained significant hearing within one month, including a seven-year-old girl who held conversations four months post-treatment.
- Duan and colleagues plan to monitor patients for five to ten years and expand research to treat other genes like GJB2 and TMC1.
45 Articles
45 Articles
Gene therapy restores hearing in toddlers and teenagers born with congenital deafness – new research
Hearing improvements were both rapid and significant after patients received the gene therapy we developed. Nina Lishchuk/ ShutterstockUp to three in every 1,000 newborns has hearing loss in one or both ears. While cochlear implants offer remarkable hope for these children, it requires invasive surgery. These implants also cannot fully replicate the nuance of natural hearing. But recent research my colleagues and I conducted has shown that a for…
New Gene Therapy Repairs Deafness Gene, Restores Hearing In Landmark Clinical Trial
A groundbreaking clinical trial has achieved what many thought impossible: restoring meaningful hearing in people born profoundly deaf, including teenagers and young adults who were previously considered too old for such treatment. The post New Gene Therapy Repairs Deafness Gene, Restores Hearing In Landmark Clinical Trial appeared first on Study Finds.
With the help of gene therapy, ten people with congenital deafness or severe hearing loss have significantly improved their hearing. – A seven-year-old girl gained almost normal hearing, says chief physician Maoli Duan to DN.
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