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Serum Institute Partners with Gates MRI to Make Experimental TB Vaccine

Serum Institute expects to invest more than $100 million to expand capacity and prepare for future supply if the vaccine is approved.

  • On Thursday, the Gates Medical Research Institute signed an agreement with the Serum Institute to manufacture the experimental tuberculosis vaccine candidate M72/AS01E.
  • Tuberculosis remains the world's leading infectious cause of death, with nearly 11 million cases in 2024, while the Bacille Calmette-Guerin vaccine is currently the only widely used option.
  • Serum Institute plans to invest more than $100 million to build manufacturing capacity, as the vaccine demonstrated around 50% protection against pulmonary TB in Phase 2b trials involving 3,575 participants.
  • The World Health Organization estimates a successful vaccine could prevent 76 million new tuberculosis cases and save 8.5 million lives, reducing costs for affected households by $41.5 billion over 25 years.
  • Gates MRI is currently sponsoring a Phase 3 clinical trial to ensure equitable access in high-burden countries, including India, which accounted for 67% of global TB cases in 2024.
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Reuters broke the news in London, United Kingdom on Thursday, July 16, 2026.
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