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Free radicals generated at a specific site in astrocytes may promote dementia
Blocking mitochondrial reactive oxygen species in astrocytes reduces brain inflammation and protects neurons, extending lifespan in mouse models of dementia, researchers found.
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Study pinpoints source of free radicals in the brain that may fuel dementia
Free radicals generated at a specific site in non-neuronal brain cells called astrocytes may promote dementia, according to a Weill Cornell Medicine study. These findings, published in Nature Metabolism, demonstrated that blocking this site lowered brain inflammation and protected neurons, suggesting a novel therapeutic approach for neurodegenerative disorders, including frontotemporal dementia and Alzheimer's disease.
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