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Reducing Saturated Fat Intake Shows Mortality Benefit, but only in High-Risk Individuals, Review Suggests

A review of 17 trials with 66,337 participants found reduced saturated fat lowers cholesterol and heart event risk in high-risk adults, especially when replaced by polyunsaturated fats.

Summary by Medical Xpress
A systematic review of 17 randomized trials found that among high cardiovascular risk individuals, reducing saturated fat was linked to lower all-cause mortality and possible reductions in cardiovascular deaths, heart attacks, and strokes. Notably, the greatest benefit for preventing nonfatal heart attacks occurred when saturated fats were replaced with polyunsaturated fats (PUFA) rather than simply reducing them.

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STAT broke the news in Boston, United States on Monday, December 15, 2025.
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