CRISPR Reveals Driver of Bone Metastasis

CRISPR Reveals Driver of Bone Metastasis

Advanced genetic screening has revealed a key driver through which cancer spreads to bones, identifying promising therapeutic agents that could help guard against this. The in vivo CRISPR activation (CRISPRa) screening system, when combined with positive selection, identified acyl-CoA binding protein (ACBP) as a new regulator of bone metastasis. The findings, in Science Translational Medicine, also revealed that etomoxir, which inhibits the oxid…

Transformationists: When cancer cells from melanoma are attacked by the immune system, they activate special genes and change their cell type. This reaction then causes, among other things, an inhibition of the T cells, which makes it easier for the skin cancer cells to settle in lymph nodes and form metastases, as researchers in "Nature Cancer" report. They also identified proteins that are characteristic for these metastasis-founding cells and…