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FDA warns of ‘rare but severe itching’ after using popular allergy medications

  • The FDA issued a warning on May 16, 2025, about rare but severe itching after stopping Zyrtec or Xyzal allergy medications in the US.
  • This warning followed reports of 209 pruritus cases mostly involving patients who used these medicines daily for weeks or months.
  • Numerous individuals reported experiencing severe itching shortly after discontinuing the medication, which significantly affected their daily activities and necessitated medical treatment.
  • The FDA acknowledged that the evidence indicates a connection, highlighting that severe cases led to outcomes such as disability, the need for inpatient care, and mental health concerns including suicidal ideation or self-injury.
  • The FDA cannot determine the exact likelihood of this reaction and urged patients to consult health professionals while requesting updated package warnings.
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MedPage Today broke the news in New York, United States on Tuesday, May 20, 2025.
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