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Novartis to Buy Excellergy for up to $2 Billion

Novartis is acquiring Excellergy's next-generation anti-IgE drug Exl-111 to strengthen its allergy portfolio amid patent expirations and revenue pressures.

  • On Friday, March 27, 2026, Palo Alto-based biotechnology firm Excellergy announced it will be acquired by Novartis in a transaction valued at up to $2 billion in upfront and milestone payments.
  • The deal centers on Excellergy's novel trifunctional Effector Cell Response Inhibitors , with lead candidate Exl-111 designed to disarm allergic effector cells by targeting the IgE axis.
  • Exl-111 is currently in Phase 1 development and has the potential to deliver faster, deeper suppression of IgE signaling and improved symptom control compared to conventional anti-IgE therapies.
  • "This acquisition validates the transformative potential of our ECRIs," said Todd Zavodnick, Chief Executive Officer of Excellergy, noting Novartis brings global capabilities to realize the medicine's full potential.
  • Fiona Marshall, President of Biomedical Research at Novartis, noted the program builds on biology the company knows well, while J.P. Morgan Securities LLC served as exclusive financial advisor.
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Excellergy specializes in the development of therapies for the possible treatment of allergic diseases such as food allergies, chronic hives or asthma.

·Düsseldorf, Germany
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Globe Newswire broke the news in on Friday, March 27, 2026.
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