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Combined Oral Contraceptive Use Associated with Threefold Increase in Stroke Risk in Young Women

  • Researchers from Istanbul University presented on May 21-23, 2025 in Helsinki that combined oral contraceptives triple cryptogenic ischemic stroke risk in women aged 18 to 49.
  • The SECRETO study compared 268 young women with sudden unexplained strokes to 268 stroke-free controls to assess stroke risk linked to combined contraceptive use.
  • After controlling for factors including smoking, hypertension, specific types of migraines, and central obesity, women who used combined hormonal contraceptives exhibited a threefold higher likelihood of experiencing a stroke of unknown cause.
  • The adjusted odds ratio was 3.00 with a 95% confidence interval of 1.61 to 5.57, and lead author Dr. Mine Sezgin stated, "Our results support previous research that associates oral contraceptive use with an increased risk of stroke."
  • These results support an association between hormonal contraceptive use and increased risk of vascular events, highlighting the importance for clinicians to thoroughly assess stroke risk in young women who have other contributing factors.
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The Sun broke the news in United Kingdom on Tuesday, May 20, 2025.
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