Targeting a Key Enzyme Could Reverse Early Parkinson's Effects

Parkinson’s reversal? One drug brings dying brain cells back to life

Stanford researchers discovered that dialing down an overactive enzyme, LRRK2, can regrow lost cellular “antennae” in key brain cells, restoring vital dopamine communication and neuroprotective signals in a mouse model of genetic Parkinson’s. After three months on the LRRK2-blocking drug MLi-2, damaged circuits revived and early signs of neuronal recovery emerged, hinting that timely treatment could not only halt but reverse disease progression—…

Targeting a key enzyme could reverse early Parkinson's effects

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson's disease that's caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice.

Inhibiting enzyme could halt cell death in Parkinson's disease, study finds

Putting the brakes on an enzyme might rescue neurons that are dying due to a type of Parkinson's disease that's caused by a single genetic mutation, according to a new Stanford Medicine-led study conducted in mice.

Reduction in Parkinson OFF Episodes Through Subcutaneous Apomorphine Infusion Leads to Doubling of Good ON Time

Continuous subcutaneous apomorphine infusion significantly reduces OFF episodes and enhances ON time in Parkinson's disease patients, improving overall health status.

Immune T-cell response may help detect Parkinson’s earlier: Study

People in the prodromal, or presymptomatic, stage of Parkinson’s disease show increased immune activity, with T cells targeting the proteins PINK1 and alpha-synuclein at levels similar to those seen in patients already diagnosed with the neurodegenerative condition, a new study reports. These two proteins — PINK1 and alpha-synuclein — are key components of Lewy bodies, the abnormal protein clumps, or aggregates, implicated in the progressive los…

A protein with a double job against neurodegeneration - Global Happenings

Discovered theUnexpected double work of a protein crucial for cells, called DDX11: in addition to playing the role of the mechanic in the nucleus of the cell, where opens the double propeller of the DNA To allow it to replication and the repairalso works as a cytoplasm for cytoplasm for region The waste recycling. This is indicated by the study conducted by the Institute of Biochemistry and Cellular Biology of the National Research Council in co…