Boosting Precision Gene Editing: Autophagy Shifts DNA Repair Toward Homologous Recombination

Boosting precision gene editing: Autophagy shifts DNA repair toward homologous recombination

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A Korean research team has become the first in the world to significantly enhance the low efficiency of a key genome editing mechanism—known as homologous recombination (HR)—by inducing autophagy, a natural process within cells.

Enhancing Precision in Gene Editing: Autophagy Revolutionizes DNA Repair

A groundbreaking advancement in the field of precision gene editing has emerged from a collaborative research effort led by Dr. Hye Jin Nam at the Korea Research Institute of Chemical Technology (KRICT). The team has successfully enhanced the efficiency of homologous recombination—a critical mechanism within the CRISPR-Cas9 technology—by inducing autophagy, a natural cellular process. This unprecedented discovery holds great promise for the trea…