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Researchers Turn a Toxic Fungus Into Cancer-Fighting Drug

UNITED STATES, JUN 23 – Scientists isolated asperigimycins from Aspergillus flavus fungus, showing selective leukemia cell-killing effects comparable to FDA-approved drugs, with plans for animal testing next.

  • On June 23, researchers at the University of Pennsylvania isolated a new class of compounds called asperigimycins from the deadly fungus Aspergillus flavus, published in Nature Chemical Biology.
  • Historically linked to mysterious deaths during tomb excavations, Aspergillus flavus was dubbed the “pharaoh’s curse” fungus due to its deadly reputation.
  • Laboratory tests show two asperigimycin variants strongly inhibit leukemia cells, with lipid modifications matching FDA-approved drugs' efficacy.
  • Researchers plan to test asperigimycins in animal models and humans, highlighting fungi’s untapped potential for new cancer therapies.
  • Beyond this study, asperigimycins could join fungi-derived medicines like penicillin, highlighting nature’s potential to inspire innovative therapies, as research reveals fungi’s untapped medical promise.
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A toxic mold known for its connection to the so-called curse of Tutankhamun's tomb could become a key weapon in the fight against cancer.

·Ljubljana, Slovenia
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Phys.org broke the news in United Kingdom on Monday, June 23, 2025.
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