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Elucidation and recreation of the biosynthetic pathway for taxol
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Elucidation and recreation of the biosynthetic pathway for taxol
Paclitaxel (sold as Taxol) is taxane diterpene natural product of yew trees (Taxus spp.) and a potent stabilizer of microtubules that is effective in treatment of cancers. However, it has proven difficult to elucidate its biosynthetic pathway, and commercial production still relies on extracting an intermediate, baccatin III, from yew tissues. In an elegant new work by McClune and Liu et al. Source
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