Elementary 3D organization of active and silenced E. coli genome

Elementary 3D organization of active and silenced E. coli genome

Unravelling how genomes are spatially organized and how their three-dimensional (3D) architecture drives cellular functions remains a major challenge in biology1,2. In bacteria, genomic DNA is compacted into a highly ordered, condensed state called nucleoid3–5. Despite progress in characterizing bacterial 3D genome architecture over recent decades6–8, the fine structure and functional organization of the nucleoid remain elusive due to low-resolu…