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Immune History Shapes Human Antibody Responses to H5N1 Influenza Viruses

Summary by Nature
Avian H5N1 influenza viruses are circulating widely in cattle and other mammals and pose a risk for a human pandemic. Previous studies suggest that older humans are more resistant to H5N1 infections due to childhood imprinting with other group 1 viruses (H1N1 and H2N2); however, the immunological basis for this is incompletely understood. Here we measured H5N1 antibody responses in sera from 157 individuals born between 1927 and 2016. We show th…

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SHTF Plan broke the news in on Friday, May 23, 2025.
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