Genetic Analyses of Early-Onset Alzheimer’s Disease Using Next Generation Sequencing

Genetic analyses of early-onset Alzheimer’s disease using next generation sequencing

Alzheimer’s disease (AD) is the most common type of neurodegenerative dementia, but the cause of AD remained poorly understood. Many mutations in the amyloid precursor protein (APP) and presenilin 1 and 2 (PSEN1 and PSEN2) have been reported as the pathogenic causes of early-onset AD (EOAD), which accounts for up to 5% of all AD cases. In this study, we screened familiar/de novo EOAD (n = 67) samples by next-generation sequencing (NGS) of a 50-g…

First large-scale stem cell bank enables worldwide studies on genetic risk for Alzheimer's disease

Alzheimer's disease (AD) is a common, debilitating neurodegenerative disease affecting about 10% of people over the age of 65 and one third of people aged 85 and above. Besides environmental factors, the genes have a strong influence on whether or not a person develops AD during their lifetime.

Early-Onset Alzheimer’s disease and amyloid precursor protein gene mutations

Early-onset Alzheimer’s disease (EOAD) is a form of Alzheimer’s disease (AD) that usually manifests before the age of 65 years and is closely l

Could A Single Brain Scan Predict The Risk Of Age-Related Conditions Like Dementia?

Written by Katharine Lang — Fact checked by Kevin Cyr, MD Some people appear to age more slowly than others. This is partly due to genetics, which studies suggest accounts for around 25% of the variation in longevity but is largely due to lifestyle and the environment. Modifications in lifestyle, such as following a healthy diet, exercising regularly, getting adequate sleep, not smoking, and not drinking alcohol to excess, can help slow a pers…

Early Identification and Diagnosis of Alzheimer Disease

Panelists discuss how primary care physicians rely on clinical observations, history-taking, and cognitive assessments—despite time and training limitations—to diagnose Alzheimer disease early, emphasizing the critical need for timely detection to enable effective interventions, lifestyle modifications, and to reduce long-term societal and health care burdens.