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49ers vs. Eagles Odds: How to Bet NFC Wild Card Matchup

Eagles plan to contain McCaffrey, who led the NFL with 413 touches, while forcing 49ers QB Purdy into mistakes to start their Super Bowl title defense.

  • On January 11, 2026, the Philadelphia Eagles will host the San Francisco 49ers at Lincoln Financial Field in the NFC Wild Card round.
  • Given his workload, Christian McCaffrey led the NFL with 413 touches and posted career-low yards-after-contact with a 31.1 rushes-per-broken-tackle rate.
  • Rushing the passer with discipline will involve the Eagles' interior defensive line pushing the pocket and edge athletes Nolan Smith and Jalyx Hunt to prevent Brock Purdy from escaping, targeting his 3.5% interception rate.
  • If the Eagles can force turnovers and limit the 49ers' run game, their 42-3 record when winning the turnover margin highlights this as a decisive factor.
  • Trent Williams' hamstring issue looms after missing Week 18, and Kyle Shanahan said on Jan. 7 he didn’t practice with uncertain status for Jan. 8; Philadelphia’s linebackers Zack Baun, Nakobe Dean, and Jihaad Campbell provide a matchup edge.
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Eagles host 49ers in wild-card round as they seek a repeat Super Bowl title

PHILADELPHIA (AP) — The Eagles declared from the first day of training camp and throughout another season that included an NFC East title that the word “repeat” is not part of the locker-room vernacular for the 2024 Super Bowl champions.

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Philly Voice broke the news in Philadelphia, United States on Wednesday, January 7, 2026.
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