Drug-Controlled CAR T Cells through the Regulation of Cell-Cell Interactions

Drug-Controlled CAR T Cells May Enable Safer Immunotherapy

Among the most promising tools of cancer therapy, engineered immune cells known as chimeric antigen-receptor (CAR) T cells have already transformed the treatment of blood cancers. Yet, despite their promise, CAR T cells do have their limitations. For one thing, they’ve so far largely failed against solid tumors, which is to say, most types of cancer. For another, they can inadvertently kill healthy cells along with cancerous ones—or, separately,…

Drug-Controlled CAR T Cells through the Regulation of Cell-Cell Interactions

Scientists combined rational design and library-based optimization of a protein–protein interaction (PPI) of human origin to develop venetoclax-controlled drug-regulated off-switch PPI -CARs. [Nature Chemical Biology] Full Article