Drug Candidate Shows Early Promise for Treating Alzheimer’s Damage

New Molecule Restores the Brain’s Natural Defenses Against Alzheimer’s

Scientists have developed an experimental molecule that helps the brain’s immune cells fight Alzheimer’s again, reducing toxic plaques and improving memory in animal studies. Scientists have identified an experimental molecule that appears to restore some of the brain’s natural defenses against Alzheimer’s disease by helping immune cells once again contain the toxic protein deposits linked [...]

Investigational drug ameliorates neuronal DNA damage and inflammation in Alzheimer's model

Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease.

Drug Candidate Shows Early Promise for Treating Alzheimer’s Damage

A drug candidate developed at King’s College London boosts DNA repair and reduces neuronal damage, as well as lowering neuroinflammation and could become a new treatment option for people with early stage Alzheimer’s disease in the future. Writing in the journal FEBS Open Bio, lead author Jonathan Corcoran, PhD, a professor at King’s College London, and colleagues report results of a study carried out in a mouse model of Alzheimer’s disease that…

Investigational drug that targets DNA damage help could treat Alzheimer's disease

Accumulation of DNA damage in the brain's neurons may contribute to the development of Alzheimer's disease. New research in FEBS Open Bio demonstrates the therapeutic potential of a drug that targets this process.

Copper compound targets Alzheimer’s at the blood-brain barrier

BY THE OPTIMIST DAILY EDITORIAL TEAM Most Alzheimer’s research goes after the toxic proteins directly. This study asks a different question: what if the brain’s own clearing system could be fixed instead? Research from Monash University’s Institute of Pharmaceutical Sciences, published in ACS Chemical Neuroscience, found that a copper compound called Cu(ATSM) repaired a waste-clearing mechanism at the blood-brain barrier, letting the brain flush…