Donor-derived dendritic cells teach the immune system to accept new livers

Organ Transplants Without Lifelong Meds? New Trial Shows It's Possible

Several liver transplant recipients have stayed off anti-rejection drugs for at least three years following an experimental therapy.

Donor-derived dendritic cells teach the immune system to accept new livers

UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a unique "immune priming" therapy.

Cell therapy primed liver transplant patients to avoid organ rejection, small study shows

Cells from living donors were injected into patients before the transplant to prime their immune system to accept the new organ with less immunosuppression.

Liver transplant patients remain drug-free for years using donor dendritic cells in trial

In a compact clinical trial at the University of Pittsburgh, four liver transplant recipients stopped taking anti-rejection drugs entirely and remained

Organ Transplants Without Lifelong Meds? New Trial Shows It’s Possible

Several liver transplant recipients have stayed off anti-rejection drugs for at least three years following an experimental therapy.

Immune Priming Could End Immunosuppression After Liver Transplant

Results from a Phase I/IIa trial show promise for an immune priming approach where donor immune cells are infused into liver transplant recipients before surgery. In the small-scale clinical trial, three patients were reported to remain completely off immunosuppression for over three years thanks to this treatment.  Recipients of organ transplants need to take lifelong medication to prevent the immune system from rejecting the transplant. In the…