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Risks of Losing Muscle Mass as Doctors Issue Stark Warning over Worrying ‘Side Effect’ of Ozempic, Mounjaro and Wegovy
- Regeneron Pharmaceuticals announced interim Phase 2 trial results of a combination therapy involving semaglutide and antibodies to preserve muscle in obesity patients.
- The trial followed concerns that semaglutide, the active drug in Ozempic and Wegovy, can cause excessive muscle loss during weight reduction, especially in vulnerable populations.
- Approximately 600 participants showed that the combination group lost more weight but only 7% of that loss was lean body mass, compared to 35% lean mass loss in the semaglutide-only group.
- George Yancopoulos of Regeneron stated that the antibody has the potential to maintain muscle mass while enhancing fat reduction in individuals undergoing treatment, although higher dosages were associated with increased side effects and a greater likelihood of participants discontinuing the study.
- These findings suggest muscle preservation may improve weight loss quality but require further validation due to incomplete data and side effect concerns.
28 Articles
28 Articles
Reuters Health News Summary
The drug candidate, trevogrumab, in combination with Novo Nordisk's popular obesity drug Wegovy, chemically known as semaglutide, helped patients preserve muscle and increase fat loss in patients, Regeneron said. Sanofi to buy US biopharma group Blueprint for up to $9.5 billion France's Sanofi has agreed to buy U.S.-based Blueprint Medicines Corporation for up to $9.5 billion to boost its position in rare immunology diseases, in the biggest deal…
Semaglutide Linked to Age-Related Macular Degeneration Risk
(MedPage Today) -- Older adults taking GLP-1 receptor agonists, primarily semaglutide (Rybelsus, Ozempic, Wegovy), had a small uptick in their risk of developing neovascular age-related macular degeneration (nAMD), according to a retrospective...
Dry mouth, bad breath and tooth damage: the effects Ozempic and Wegovy can have on your mouth
Bad breath is a commonly reported side-effect of weight loss drugs. antoniodiaz/ ShutterstockOzempic and Wegovy have been hailed as wonder drugs when it comes to weight loss. But as the drug has become more widely used, a number of unintended side-effects have become apparent – with the weight loss drug affecting the appearance of everything from your butt to your feet. “Ozempic face” is another commonly reported consequences of using these popu…
The new weight-loss PILLS set to rival fat jabs - and they'll be cheaper
EVERYONE’S talking about fat jabs – the ‘miracle’ injections trimming inches off waistlines, and helping turn the tide on the obesity epidemic. But what if there was an even easier – and cheaper – way than Ozempic-like injections, Wegovy and Mounjaro? GettySlimming tablets have been around for decades – but now scientists want to harness the new momentum in obesity medicine to bring them back with a bang[/caption] GettyRival company Eli Lilly, w…
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