Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia

Distinct contributions of two subpopulations of subthalamic neurons to levodopa-induced dyskinesia

Abstract The subthalamic nucleus (STN) is a prominent target for deep-brain stimulation (DBS) in the treatment of levodopa-induced dyskinesia (LID), a common motor complication of Parkinson’s disease. However, the precise impact of STN-DBS on LID remains unclear. Here, we investigated the functional roles of two distinct neuronal populations within the STN in regulating LID. In a mouse model of LID, STN neurons projecting to the entopeduncular n…