Discovering Residual Pathways Driving Asthma Exacerbations in the Era of Biologic Therapy

Discovering Residual Pathways Driving Asthma Exacerbations in the Era of Biologic Therapy

Severe exacerbations remain the major driver of morbidity and mortality in children and adolescents with asthma. Elucidating biologic mechanisms underlying exacerbations is a critical area of ongoing study to further reduce asthma burden. Over the past 2 decades, improved understanding of immune dysregulation in asthma has led to the development and approval of biologic therapies that reduce underlying allergic airway inflammation and exacerbati…