Diet and Microbiome Influence Immunotherapy Success in Obesity

Diet and Microbiome Influence Immunotherapy Success in Obesity

A groundbreaking study published in Nature unveils a critical synergy between diet and the gut microbiome that underpins obesity-associated efficacy of immune checkpoint inhibitors (ICIs) in cancer therapy. Researchers identify the bacterium Lactobacillus johnsonii as a key microbial species enriched in mice fed obesogenic, ICI-responsive diets such as High Fat and American-style regimens. This bacterial enrichment correlates with improved anti-…

Gut Microbiome Signatures Correlate With Clinical Efficacy in Immunotherapy Outcomes

Cancer remains notoriously difficult to treat, partly because tumors co‑opt their surrounding environment, including the resident microbiota, to evade immune surveillance and resist conventional therapies.