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DeepMind’s new AlphaGenome AI tackles the ‘dark matter’ in our DNA

  • On June 25, 2025, Google DeepMind unveiled AlphaGenome, an AI model capable of processing up to one million DNA base pairs to predict non-coding variant effects.
  • Since 98% of the human genome's non-coding regions remain poorly understood, decoding their functions has hindered disease variant interpretation.
  • AlphaGenome outperforms 24 of 26 genomic benchmarks, processing up to one million base pairs using a U-Net transformer architecture.
  • Following the June 25, 2025, API release, researchers worldwide can access AlphaGenome for non-commercial genomic research, potentially accelerating disease variant discovery.
  • DeepMind's AlphaGenome, set to be expanded to other species and modalities, aims to advance long-term discoveries and improve disease variant interpretation globally.
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We know that, in terms of Artificial Intelligence (IA), the sky may not be the limit. In fact, the potentials are many and companies have tried to explore them. This time, by Google's hands, it was...

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AlphaGenome designed to decipher non-coding sequences (ANSA)

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Nature broke the news in United Kingdom on Wednesday, June 25, 2025.
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