US EditionDeepMind Unveils AlphaGenome AI to Predict Gene Mutations
AlphaGenome predicts effects of mutations in DNA sequences up to one million base pairs, used by 3,000 researchers from 160 countries via an API since June 2025.
- On Wednesday, Google DeepMind unveiled AlphaGenome, an AI tool to help unravel the human genome and potentially aid treatments, with the work detailed in a Nature study and earlier blog post.
- Because only around two percent codes for proteins, the human genome contains three billion letters, and the 'dark genome' comprises the remaining 98% of non-coding DNA with many disease-linked variants.
- AlphaGenome operates as a sequence-to-function model that predicts nucleotide changes' effects, analysing up to one million DNA letters and comparing mutated vs non-mutated sequences, trained on public human and mouse cell/tissue datasets.
- Since its launch seven months ago, nearly 3,000 scientists across 160 countries have started using AlphaGenome to study cancer and other diseases, with about 1 million API calls per day via DeepMind's free API.
- Experts praised the advance but warned of limits, with Ben Lehner calling AlphaGenome a 'breakthrough' yet DeepMind noting lower accuracy for long-range regulatory predictions beyond 100,000 letters, while Pushmeet Kohli urged, `We hope researchers will extend it with more data.
69 Articles
69 Articles
Google DeepMind Unveils New AI Tool To Understand DNA Mutations
Google DeepMind has revealed a new artificial intelligence system, AlphaGenome, which, the researchers say, could help scientists better interpret the human genome and understand how genetic changes affect biology.
Advancing regulatory variant effect prediction with AlphaGenome
Deep learning models that predict functional genomic measurements from DNA sequences are powerful tools for deciphering the genetic regulatory code. Existing methods involve a trade-off between input sequence length and prediction resolution, thereby limiting their modality scope and performance1–5. We present AlphaGenome, a unified DNA sequence model, which takes as input 1 Mb of DNA sequence and predicts thousands of functional genomic tracks …
The vast majority of human genetics are riddles for researchers. Deepmind AI software can now better understand the function of DNA. Can major medical questions be solved with mutants in the computer in the future?
Google has released its AI tool, AlphaGenome, which analyzes how parts of DNA regulate the activity of genes in the cell.
DeepMind's new AI AlphaGenome decodes how genes are controlled. It shows how switches and genes interact - a breakthrough for research and a step towards personalized medicine. By Frank Wittig and Ralf Kölbel.
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