Data-driven 3D chromosome model reveals structural and dynamic features of DNA

Data-driven 3D chromosome model reveals structural and dynamic features of DNA

Chromosomes are masters of organization. These long strings of DNA fold down into an ensemble of compact structures that keep needed parts of the genome accessible while tucking away those that aren't used as often. Understanding the complexity of these structures has been challenging; chromosomes are large systems, and deciphering the structure and dynamics requires a combination of experimental data and theoretical approaches.