US EditionTest Can Detect Crohn’s Disease Years Before Symptoms Show
The test detects an immune response to bacterial protein flagellin in genetically at-risk relatives, identifying over one third of future Crohn’s cases before symptoms appear.
- Sinai Health researchers identified a blood test that signals Crohn’s disease risk years before symptoms appear, reporting their findings in Clinical Gastroenterology and Hepatology.
- Because diagnosis often follows intestinal damage, the GEM Project tracks more than 5,000 healthy first-degree relatives to study Crohn’s onset.
- The test measures serum IgG response to flagellin, including Lachnospiraceae flagellin, with 28 individuals showing elevated antibodies and siblings having the strongest inflammation signals.
- If confirmed, the test could enable earlier diagnosis and possible prevention to reduce intestinal damage, but researchers caution antibodies appeared only in a subset and validation and mechanistic studies are underway.
- The GEM Project’s tracking of more than 5,000 first-degree relatives positions the research to influence screening strategies as IBD rates rise, and future validation studies are planned.
20 Articles
20 Articles
Discovery carried out by Canadian institute early diagnosis by means of blood tests that measure the immune response of antibodies. Study aims at the development of preventive vaccines.
ABC FOX Montana
Test can detect Crohn’s disease years before symptoms show
The discovery opens the door to early diagnosis and potential prevention of the chronic form of inflammatory bowel disease.
Crohn’s Disease May Be Detectable Years Before Symptoms
A blood test may detect Crohn’s disease years before it strikes—changing how the condition is predicted and prevented. Researchers at Sinai Health have identified a blood test that can signal the risk of Crohn’s disease years before symptoms begin. The discovery raises the possibility of earlier diagnosis and, eventually, prevention for a condition that is [...]
Blood Test Could Predict Crohn’s Disease Years Before Symptoms Appear
Research led by Mount Sinai Hospital in Toronto shows antibodies against flagellin, the main protein that makes up the long tail on many gut bacteria, can be found in the blood of a significant proportion of at risk people who go on to develop Crohn’s disease. The antibody response observed by the researchers was mainly directed at a small section of the flagellin protein, known as the hinge region, from normal gut bacteria and could be detected…
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